Draft:Pramiverine
| Submission declined on 18 December 2024 by WeirdNAnnoyed (talk). The subject exists, and the sources appear to be reliable (although I was unable to access any of them, except for the abstracts on PubMed). The problem is that the article's text is written in a fragmentary manner that is extremely difficult to understand. Furthermore, all citations are provided in the first (incomplete) sentence, but the specific statements made in the main paragraph are unsourced. If the author's first language is not English, I suggest a translation service. Also, inline citations should be provided to the statements in the main paragraph.
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| Other names | Cintaverin, Monoverin, Propaminodiphene, Raptalgin, Sistalcin, Sistalgin, Syntaverin, EMD 9806, HSp 2986. |
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| Chemical and physical data | |
| Formula | C21H27N |
| Molar mass | 293.454 g·mol−1 |
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Pramiverine is a spasmolytic and cholinolytic analgesic drug.[1][2][3][4][5]
Having the amino group located outside of a 6 membered piperidine is certainly less common, and this method does not involve mustards. Budipine/Prodipine are almost identical in this regard. SIR 117 is also based on the same gross structure and heavily relies on the same basic synthesis technique as outlined at Cutter Laboratories in the 1960’s. Lednicer himself made many butyrophenones out of this exocyclic cyclohexamine atypical outlay that is different from piperidine. For example, U-32,802A is evident.
References
[edit]- ^ Morel CJ (April 1976). "[Experimental studies on pramiverine (author's transl)]". Arzneimittel-Forschung (in German). 26 (4b): 699–702. PMID 989018.
- ^ Enenkel HJ, Müller-Calgan H, Schorscher E (April 1976). "[On the cholinolytic activity of pramiverine]". Arzneimittel-Forschung (in German). 26 (4b): 690–6. PMID 821493.
- ^ Niemann H, Jakob G (April 1976). "[Eosphagomanometric finding in man after intravenous administration of a new cholinolytic (pramiverine), atropine and scopolamine butylbromide]". Arzneimittel-Forschung (in German). 26 (4b): 728–30. PMID 989022.
- ^ Chieri RA (April 1976). "[Animal experimental study on spasmolytic and analgesic activities of pramiverine, metamizole and their combination (author's transl)]". Arzneimittel-Forschung (in German). 26 (4b): 696–8. PMID 989017.
- ^ Koch E (April 1976). "[Profile comment on clinical and experimental studies of pramiverine and pramiverine/metamizole (author's transl)]". Arzneimittel-Forschung (in German). 26 (4b): 686–9. PMID 782469.