Oligodynamic effect
The oligodynamic effect (from Greek oligos, "few", and dynamis, "force") is a biocidal effect of metals, especially heavy metals, that occurs even in low concentrations. This effect is attributed to the antibacterial behavior of metal ions, which are absorbed by bacteria upon contact and damage their cell membranes.[1]
In modern times, the effect was observed by Carl Nägeli, although he did not identify the cause.[2] Brass doorknobs, brass handrails, and silverware all exhibit this effect to an extent.
Mechanism
[edit]The metals react with thiol (-SH) or amine (-NH(1,2,3)) groups of proteins, a mode of action to which microorganisms may develop resistance. Such resistance may be transmitted by plasmids.[3]
List of uses
[edit]Aluminium
[edit]Aluminium has been found to compete with iron and magnesium and bind to DNA, membranes, or cell walls, leading to its toxic effect on microbes, such as cyanobacteria, soil bacteria and mycorrhizal fungi.[4]
Aluminium triacetate (Burow's solution) is used as an astringent mild antiseptic.[5]
Antimony
[edit]Orthoesters of diarylstibinic acids are fungicides and bactericides, used in paints, plastics, and fibers.[6] Trivalent organic antimony was used in therapy for schistosomiasis.[7]
Arsenic
[edit]For many decades, arsenic was used medicinally to treat syphilis. It is still used in sheep dips, rat poisons, wood preservatives, weed killers, and other pesticides. Arsenic is poisonous if it enters the human body.[8]
Barium
[edit]Barium polysulfide is a fungicide and acaricide used in fruit and grape growing.[9]
Bismuth
[edit]Bismuth compounds have been used because of their astringent, antiphlogistic, bacteriostatic, and disinfecting actions. In dermatology bismuth subgallate is still used in vulnerary salves and powders as well as in antimycotics.[10] In the past, bismuth has also been used to treat syphilis and malaria.[11]
Boron
[edit]Boric acid esters derived from glycols (example, organo-borate formulation, Biobor JF) are being used for the control of microorganisms in fuel systems containing water.[12]
Copper
[edit]Brass vessels release a small amount of copper ions into stored water, thus killing fecal bacterial counts as high as 1 million bacteria per milliliter.[13]
Copper sulfate mixed with lime (Bordeaux mixture) is used as a fungicide and antihelminthic.[14] Copper sulfate is used chiefly to destroy green algae (algicide) that grow in reservoirs, stock ponds, swimming pools, and fish tanks. Copper 8-hydroxyquinoline is sometimes included in paint to prevent mildew.[15]
Paint containing copper is used on boat bottoms to prevent barnacle growth (biofouling).
Copper also has the ability to destroy viruses, such as influenza viruses, noroviruses or human immunodeficiency virus (HIV).[16]
Gold
[edit]Gold is used in dental inlays and inhibits the growth of bacteria.[17]
Lead
[edit]Physicians prescribed various forms of lead to heal ailments ranging from constipation to infectious diseases such as the plague. Lead was also used to preserve or sweeten wine.[18] Lead arsenate is used in insecticides and herbicides.[19] Some organic lead compounds are used as industrial biocides: thiomethyl triphenyllead is used as an antifungal agent, cotton preservative, and lubricant additive; thiopropyl triphenyllead as a rodent repellant; tributyllead acetate as a wood and cotton preservative; tributyllead imidazole as a lubricant additive and cotton preservative.[20]
Mercury
[edit]Phenylmercuric borate and acetate were used for disinfecting mucous membranes at an effective concentration of 0.07% in aqueous solutions. Due to toxicological and ecotoxicological reasons phenylmercury salts are no longer in use. However, some surgeons use mercurochrome despite toxicological objections.[3] Mercurochrome is still available to purchase in Australia to use on minor wounds. Dental amalgam used in fillings inhibits bacterial reproduction.[13]
Organic mercury compounds have been used as topical disinfectants (thimerosal, nitromersol, and merbromin) and preservatives in medical preparations (thimerosal) and grain products (both methyl and ethyl mercurials). Mercury was used in the treatment of syphilis. Calomel was commonly used in infant teething powders in the 1930s and 1940s. Mercurials are also used agriculturally as insecticides and fungicides.[21]
Nickel
[edit]The toxicity of nickel to bacteria, yeasts, and fungi differs considerably.[22]
Silver
[edit]The metabolism of bacteria is adversely affected by silver ions at concentrations of 0.01–0.1 mg/L. Therefore, even less soluble silver compounds, such as silver chloride, also act as bactericides or germicides, but not the much less soluble silver sulfide. In the presence of atmospheric oxygen, metallic silver also has a bactericidal effect due to the formation of silver oxide, which is soluble enough to cause it. Even objects with a solid silver surface (e.g., table silver, silver coins, or silver foil) have a bactericidal effect. Silver drinking vessels were carried by military commanders on expeditions for protection against disease. It was once common to place silver foil or even silver coins on wounds for the same reason.[23]
Silver sulfadiazine is used as an antiseptic ointment for extensive burns. An equilibrium dispersion of colloidal silver with dissolved silver ions can be used to purify drinking water at sea.[3] Silver is incorporated into medical implants and devices such as catheters. Surfacine (silver iodide) is a relatively new antimicrobial for application to surfaces. Silver-impregnated wound dressings have proven especially useful against antibiotic-resistant bacteria. Silver nitrate is used as a hemostatic, antiseptic and astringent. At one time, many states[clarification needed] required that the eyes of newborns be treated with a few drops of silver nitrate to guard against an infection of the eyes called gonorrheal neonatal ophthalmia, which the infants might have contracted as they passed through the birth canal. Silver ions are increasingly incorporated into many hard surfaces, such as plastics and steel, as a way to control microbial growth on items such as toilet seats, stethoscopes, and even refrigerator doors. Among the newer products being sold are plastic food containers infused with silver nanoparticles, which are intended to keep food fresher, and silver-infused athletic shirts and socks, which claim to minimize odors.[15][17]
Thallium
[edit]Thallium compounds such as thallium sulfate have been used for impregnating wood and leather to kill fungal spores and bacteria, and for the protection of textiles from attack by moths.[24] Thallium sulfate has been used as a depilatory and in the treatment of venereal disease, skin fungal infections, and tuberculosis.[25]
Tin
[edit]Tetrabutyltin is used as an antifouling paint for ships, for the prevention of slimes in industrial recirculating water systems, for combating freshwater snails that cause bilharzia, as a wood and textile preservative, and as a disinfectant. Tricyclohexyltin hydroxide is used as an acaricide. Triphenyltin hydroxide and triphenyltin acetate are used as fungicides.[26]
Zinc
[edit]Zinc oxide is used as a weak antiseptic and in paints as a white pigment and mold-growth inhibitor.[27] Zinc chloride is a common ingredient in mouthwashes and deodorants, and zinc pyrithione is an ingredient in antidandruff shampoos. Galvanized (zinc-coated) fittings on roofs impede the growth of algae. Copper- and zinc-treated shingles are available.[15] Zinc iodide and zinc sulfate are used as topical antiseptics.[28]
Safety
[edit]Besides the individual toxic effects of each metal, a wide range of metals are nephrotoxic in humans and/or in animals.[29] Some metals and their compounds are carcinogenic to humans.[citation needed] A few metals, such as lead and mercury, can cross the placental barrier and adversely affect fetal development.[30] Several (cadmium, zinc, copper, and mercury) can induce special protein complexes called metallothioneins.[31]
See also
[edit]References
[edit]- ^ Han, Seonggeun; Kim, Jaewon; Lee, Youngseok; Bang, Junhyuk; Kim, Cheol Gyun; Choi, Junhwa; Min, Jinki; Ha, Inho; Yoon, Yeosang; Yun, Cheol-Heui; Cruz, Mutya; Wiley, Benjamin J.; Ko, Seung Hwan (12 January 2022). "Transparent Air Filters with Active Thermal Sterilization". Nano Letters. 22 (1): 524–532. Bibcode:2022NanoL..22..524H. doi:10.1021/acs.nanolett.1c02737. ISSN 1530-6984. PMID 34665632.
- ^ Nägeli, Karl Wilhelm (1893), "Über oligodynamische Erscheinungen in lebenden Zellen", Neue Denkschriften der Allgemeinen Schweizerischen Gesellschaft für die Gesamte Naturwissenschaft, XXXIII (1)
- ^ a b c Harke, Hans-P. (2007), "Disinfectants", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–17, doi:10.1002/14356007.a08_551, ISBN 978-3527306732
- ^ Piña, Rogelio Garcidueñas; Cervantes, Carlos (1996). "Microbial interactions with aluminium". BioMetals. 9 (3): 311–316. doi:10.1007/BF00817932. ISSN 0966-0844. PMID 8696081.
- ^ Berth-Jones, John (2010), "Topical Therapy", in Burns, Tony; Breathnach, Stephen; Cox, Neil; Griffiths, Christopher (eds.), Rook's Textbook of Dermatology, vol. 4 (8th ed.), Wiley-Blackwell, p. 73.16, ISBN 978-1-4051-6169-5
- ^ Grund, Sabina C.; Hanusch, Kunibert; Breunig, Hans J.; Wolf, Hans Uwe (2007), "Antimony and Antimony Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–34, doi:10.1002/14356007.a03_055.pub2, ISBN 978-3527306732
- ^ Leikin, Jerrold B.; Paloucek, Frank P., eds. (2008), "Antimony", Poisoning and Toxicology Handbook (4th ed.), Informa, p. 753, ISBN 978-1-4200-4479-9
- ^ Kapp, Robert (2005), "Arsenic", Encyclopedia of Toxicology, vol. 1 (2nd ed.), Elsevier, pp. 168–171, ISBN 978-0-12-745354-5
- ^ Kresse, Robert; Baudis, Ulrich; Jäger, Paul; Riechers, H. Hermann; Wagner, Heinz; Winkler, Jochen; Wolf, Hans Uwe (2007), "Barium and Barium Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–21, CiteSeerX 10.1.1.150.8925, doi:10.1002/14356007.a03_325.pub2, ISBN 978-3527306732
- ^ Krüger, Joachim; Winkler, Peter; Lüderitz, Eberhard; Lück, Manfred; Wolf, Hans Uwe (2007), "Bismuth, Bismuth Alloys, and Bismuth Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–22, doi:10.1002/14356007.a04_171, ISBN 978-3527306732
- ^ Gad, Shayne C.; Mehendale, Harihara M. (2005), "Bismuth", Encyclopedia of Toxicology, vol. 1 (2nd ed.), Elsevier, pp. 312–314, ISBN 978-0-12-745354-5
- ^ Brotherton, Robert J.; Weber, C. Joseph; Guibert, Clarence R.; Little, John L. (2007), "Boron Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–23, doi:10.1002/14356007.a04_309, ISBN 978-3527306732
- ^ a b Bauman, Robert W. (2012), Microbiology with diseases by body system (3rd ed.), Benjamin Cummings, pp. 278–279, ISBN 978-0-321-71271-4
- ^ Gad, Shayne C. (2005), "Copper", Encyclopedia of Toxicology, vol. 1 (2nd ed.), Elsevier, pp. 665–667, ISBN 978-0-12-745354-5
- ^ a b c Tortora, Gerard J.; Funke, Berdell R.; Case, Christine L. (2010), Microbiology: An Introduction (10th ed.), Benjamin Cummings, pp. 300–301, ISBN 978-0-321-55007-1
- ^ Vincent, M.; Duval, R.E.; Hartemann, P.; Engels-Deutsch, M. (2018). "Contact killing and antimicrobial properties of copper". Journal of Applied Microbiology. 124 (5): 1032–1046. doi:10.1111/jam.13681. ISSN 1364-5072. PMID 29280540.
- ^ a b Cowan, Marjorie Kelly (2012), Microbiology: A Systems Approach (3rd ed.), McGraw-Hill Education, pp. 320–321, ISBN 978-0-07-352252-4
- ^ Sutherland, Charles A.; Milner, Edward F.; Kerby, Robert C.; Teindl, Herbert; Melin, Albert; Bolt, Hermann M. (2007), "Lead", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, doi:10.1002/14356007.a15_193.pub2, ISBN 978-3527306732
- ^ Gad, Shayne C. (2005), "Lead", in Wexler, Philip (ed.), Encyclopedia of Toxicology, vol. 2 (2nd ed.), Elsevier, pp. 705–709, ISBN 978-0-12-745354-5
- ^ Carr, Dodd S. (2007), "Lead Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–10, doi:10.1002/14356007.a15_249, ISBN 978-3527306732
- ^ Gad, Shayne C. (2005), "Mercury", Encyclopedia of Toxicology, vol. 3 (2nd ed.), Elsevier, pp. 36–39, ISBN 978-0-12-745354-5
- ^ Lascelles, Keith; Morgan, Lindsay G.; Nicholls, David; Beyersmann, Detmar (2007), "Nickel Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–16, doi:10.1002/14356007.a17_235.pub2, ISBN 978-3527306732
- ^ Renner, Hermann; Schlamp, Günther; Zimmermann, Klaus; Weise, Wolfgang; Tews, Peter; Dermann, Klaus; Knödler, Alfons; Schröder, Karl-Heinz; Kempf, Bernd; Lüschow, Hans Martin; Drieselmann, Ralf; Peter, Catrin; Schiele, Rainer (2007), "Silver, Silver Compounds, and Silver Alloys", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–17, doi:10.1002/14356007.a24_107, ISBN 978-3527306732
- ^ Micke, Heinrich; Wolf, Hans Uwe (2007), "Thallium and Thallium Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–14, doi:10.1002/14356007.a26_607, ISBN 978-3527306732
- ^ Gad, Shayne C. (2005), "Thallium", Encyclopedia of Toxicology, vol. 4 (2nd ed.), Elsevier, pp. 165–166, ISBN 978-0-12-745354-5
- ^ Graf, Günter G. (2007), "Tin, Tin Alloys, and Tin Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–35, doi:10.1002/14356007.a27_049, ISBN 978-3527306732
- ^ Leikin, Jerrold B.; Paloucek, Frank P., eds. (2008), "Zinc Oxide", Poisoning and Toxicology Handbook (4th ed.), Informa, p. 705, ISBN 978-1-4200-4479-9
- ^ Rohe, Dieter M. M.; Wolf, Hans Uwe (2007), "Zinc Compounds", Ullmann's Encyclopedia of Industrial Chemistry (7th ed.), Wiley, pp. 1–6, doi:10.1002/14356007.a28_537, ISBN 978-3527306732
- ^ Rankin, Gary O. (2005), "Kidney", Encyclopedia of Toxicology, vol. 2 (2nd ed.), Elsevier, pp. 666–689, ISBN 978-0-12-745354-5
- ^ NHMRC Information Paper: Evidence on the Effects of Lead on Human Health, National Health and Medical Research Council, 2015, ISBN 978-1-925129-36-6
- ^ Gad, Shayne C. (2005), "Metals", in Wexler, Philip (ed.), Encyclopedia of Toxicology, vol. 3 (2nd ed.), Elsevier, p. 49, ISBN 978-0-12-745354-5
Links
[edit]- Lilaria, Khushboo; Gupta, Nisha; Paul, Jai Shankar; Jadhav, Shailesh Kumar (31 December 2020). "Comparative Analysis of Oligodynamic Virtue of Various Metals on Bacterial Population". NewBioWorld. 2 (2): 8–12. doi:10.52228/NBW-JAAB.2020-2-2-3.